Wetenschappelijk onderzoek
In de Barrett Expert Centra wordt wetenschappelijk onderzoek gedaan bij Barrett patiënten. Het onderzoek richt zich op drie belangrijke aspecten :
- Een betere endoscopische controle van het Barrett slijmvlies door middel van nieuwe endoscopische technieken voor beeldvorming.
- Het identificeren van biologische markers die kunnen worden gebruikt om onrustige cellen op te sporen en om te kunnen voorspellen welke patiënten een hoger risico hebben om onrustige cellen te ontwikkelen.
- Nieuwe behandelingsvormen van dysplasie en vroege vormen van slokdarmkanker.
Wanneer u in een van de Barrett Expert Centra een afspraak heeft in verband met uw Barrett slokdarm is de kans groot dat u benaderd wordt voor wetenschappelijk onderzoek. Er kan bijvoorbeeld toestemming gevraagd worden voor het nemen van extra biopten tijdens de gastroscopie, of toestemming om een nieuwe behandelmethode toe te passen.
Alle onderzoeksprojecten worden beoordeeld door de medisch ethische commissie van de deelnemende ziekenhuizen.
Lopende onderzoeken
Onderzoek naar het verbeteren van beeldvorming en diagnostiek:
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Afgeronde onderzoeken
Hieronder een lijst met referenties van onderzoek gepubliceerd in wetenschappelijke vaktijdschriften.
• Swager A, de Groof AJ, Meijer SL, Weusten BL, Curvers WL, Bergman JJ. Feasibility of laser marking in Barrett’s esophagus with Volumetric laser endomicroscopy First-in-man pilot study. Gastrointest Endosc. 2017 Feb 1. pii: S0016-5107(17)30074-3. doi: 10.1016/j.gie.2017.01.030. [Epub ahead of print] PubMed PMID: 28161451.
• Duits LC, van der Wel MJ, Cotton CC, Phoa KN, Ten Kate FJ, Seldenrijk CA, Offerhaus GJ, Visser M, Meijer SL, Mallant-Hent RC, Krishnadath KK, Pouw RE, Tijssen JG, Shaheen NJ, Bergman JJ. Patients With Barrett’s Esophagus and Confirmed Persistent Low-grade Dysplasia at Increased Risk for Progression to Neoplasia. Gastroenterology. 2016 Dec 21. pii: S0016-5085(16)35506-8. doi: 10.1053/j.gastro.2016.12.008. [Epub ahead of print]
• Rosmolen WD, Nieuwkerk PT, Pouw RE, van Berge Henegouwen MI, Bergman JJ, Sprangers MA. Quality of life and fear of cancer recurrence after endoscopic treatment for early Barrett’s neoplasia: a prospective study. Dis Esophagus. 2016 Oct 21. doi: 10.1111/dote.12512. [Epub ahead of print]
• Swager AF, Tearney GJ, Leggett CL, van Oijen MG, Meijer SL, Weusten BL, Curvers WL, Bergman JJ. Identification of volumetric laser endomicroscopy features predictive for early neoplasia in Barrett’s esophagus using high-quality histological correlation. Gastrointest Endosc. 2016 Sep 19. pii: S0016-5107(16)30581-8. doi: 10.1016/j.gie.2016.09.012. [Epub ahead of print]
• van der Sommen F, Zinger S, Curvers WL, Bisschops R, Pech O, Weusten BL, Bergman JJ, de With PH, Schoon EJ. Computer-aided detection of early neoplastic lesions in Barrett’s esophagus. Endoscopy. 2016 Jul;48(7):617-24.
• Barret M, Belghazi K, Weusten BL, Bergman JJ, Pouw RE. Single-session endoscopic resection and focal radiofrequency ablation for short-segment Barrett’s esophagus with early neoplasia. Gastrointest Endosc. 2016 Jul;84(1):29-36.
• Van Vilsteren FG, Pouw RE, Alvarez Herrero L, Bisschops R, Houben M, Peters FT, Schenk BE, Weusten BL, Schoon EJ, Bergman JJ. Learning endoscopic resection in the esophagus. Endoscopy. 2015 Nov;47(11):972-9.
• Swager AF, Boerwinkel DF, de Bruin DM, Faber DJ, van Leeuwen TG, Weusten BL, Meijer SL, Bergman JJ, Curvers WL. Detection of buried Barrett’s glands after radiofrequency ablation with volumetric laser endomicroscopy. Gastrointest Endosc. 2016 Jan;83(1):80-8.
• Schölvinck DW, Belghazi K, Pouw RE, Curvers WL, Weusten BL, Bergman JJ. In vitro assessment of the performance of a new multiband mucosectomy device for endoscopic resection of early upper gastrointestinal neoplasia. Surg Endosc. 2016 Feb;30(2):471-9.
• Swager A, Boerwinkel DF, de Bruin DM, Weusten BL, Faber DJ, Meijer SL, van Leeuwen TG, Curvers WL, Bergman JJ. Volumetric laser endomicroscopy in Barrett’s esophagus: a feasibility study on histological correlation. Dis Esophagus. 2016 Aug;29(6):505-12.
• Phoa KN, Pouw RE, Bisschops R, Pech O, Ragunath K, Weusten BL, Schumacher B, Rembacken B, Meining A, Messmann H, Schoon EJ, Gossner L, Mannath J, Seldenrijk CA, Visser M, Lerut T, Seewald S, ten Kate FJ, Ell C, Neuhaus H, Bergman JJ. Multimodality endoscopic eradication for neoplastic Barrett oesophagus: results of an European multicentre study (EURO-II). Gut. 2016 Apr;65(4):555-62.
• Duits LC, Phoa KN, Curvers WL, Ten Kate FJ, Meijer GA, Seldenrijk CA, Offerhaus GJ, Visser M, Meijer SL, Krishnadath KK, Tijssen JG, Mallant-Hent RC, Bergman JJ. Barrett’s oesophagus patients with low-grade dysplasia can be accurately risk-stratified after histological review by an expert pathology panel. Gut. 2015 May;64(5):700-6.
• Boerwinkel DF, Shariff MK, di Pietro M, Holz JA, Aalders MC, Curvers WL, Fitzgerald RC, Bergman JJ. Fluorescence imaging for the detection of early neoplasia in Barrett’s esophagus: old looks or new vision? Eur J Gastroenterol Hepatol. 2014 Jul;26(7):691-8.
• Boerwinkel DF, Holz JA, Hawkins DM, Curvers WL, Aalders MC, Weusten BL, Visser M, Meijer SL, Bergman JJ. Fluorescence spectroscopy incorporated in an Optical Biopsy System for the detection of early neoplasia in Barrett’s esophagus. Dis Esophagus. 2015 May-Jun;28(4):345-51.
• Alvarez Herrero L, Curvers WL, Bisschops R, Kara MA, Schoon EJ, ten Kate FJ, Visser M, Weusten BL, Bergman JJ. Narrow band imaging does not reliably predict residual intestinal metaplasia after radiofrequency ablation at the neo-squamocolumnar junction. Endoscopy. 2014 Feb;46(2):98-104.
• Pouw RE, Visser M, Odze RD, Sondermeijer CM, ten Kate FJ, Weusten BL, Bergman JJ. Pseudo-buried Barrett’s post radiofrequency ablation for Barrett’s esophagus, with or without prior endoscopic resection. Endoscopy. 2014 Feb;46(2):105-9.
• Alvarez Herrero L, Curvers WL, van Vilsteren FG, Wolfsen H, Ragunath K, Wong Kee Song LM, Mallant-Hent RC, van Oijen A, Scholten P, Schoon EJ, Schenk EB, Weusten BL, Bergman JG. Validation of the Prague C&M classification of Barrett’s esophagus in clinical practice. Endoscopy. 2013 Nov;45(11):876-82.
• Boerwinkel DF, Holz JA, Kara MA, Meijer SL, Wallace MB, Wong Kee Song LM, Ragunath K, Wolfsen HC, Iyer PG, Wang KK, Weusten BL, Aalders MC, Curvers WL, Bergman JJ. Effects of autofluorescence imaging on detection and treatment of early neoplasia in patients with Barrett’s esophagus. Clin Gastroenterol Hepatol. 2014 May;12(5):774-81.
• Van Vilsteren FG, Alvarez Herrero L, Pouw RE, Schrijnders D, Sondermeijer CM, Bisschops R, Esteban JM, Meining A, Neuhaus H, Parra-Blanco A, Pech O, Ragunath K, Rembacken B, Schenk BE, Visser M, ten Kate FJ, Meijer SL, Reitsma JB, Weusten BL, Schoon EJ, Bergman JJ. Predictive factors for initial treatment response after circumferential radiofrequency ablation for Barrett’s esophagus with early neoplasia: a prospective multicenter study. Endoscopy. 2013 Jul;45(7):516-25.
• Phoa KN, Pouw RE, van Vilsteren FG, Sondermeijer CM, Ten Kate FJ, Visser M, Meijer SL, van Berge Henegouwen MI, Weusten BL, Schoon EJ, Mallant-Hent RC, Bergman JJ. Remission of Barrett’s esophagus with early neoplasia 5 years after radiofrequency ablation with endoscopic resection: a Netherlands cohort study. Gastroenterology. 2013 Jul;145(1):96-104.
• Van Vilsteren FG, Phoa KN, Alvarez Herrero L, Pouw RE, Sondermeijer CM, Visser M, Ten Kate FJ, van Berge Henegouwen MI, Weusten BL, Schoon EJ, Bergman JJ. A simplified regimen for focal radiofrequency ablation of Barrett’s mucosa: a randomized multicenter trial comparing two ablation regimens. Gastrointest Endosc. 2013 Jul;78(1):30-8.
• Van Vilsteren FG, Phoa KN, Alvarez Herrero L, Pouw RE, Sondermeijer CM, van Lijnschoten I, Seldenrijk KA, Visser M, Meijer SL, van Berge Henegouwen MI, Weusten BL, Schoon EJ, Bergman JJ. Circumferential balloon-based radiofrequency ablation of Barrett’s esophagus with dysplasia can be simplified, yet efficacy maintained, by omitting the cleaning phase. Clin Gastroenterol Hepatol. 2013
• May;11(5):491-98.
• Van Vilsteren FG, Alvarez Herrero L, Pouw RE, Visser M, Ten Kate FJ, van Berge Henegouwen MI, Schoon EJ, Weusten BL, Bergman JJ. Radiofrequency ablation and endoscopic resection in a single session for Barrett’s esophagus containing early neoplasia: a feasibility study. Endoscopy. 2012 Dec;44(12):1096-104.
• Van Vilsteren FG, Pouw RE, Herrero LA, Peters FP, Bisschops R, Houben M, Peters FT, Schenk BE, Weusten BL, Visser M, Ten Kate FJ, Fockens P, Schoon EJ, Bergman JJ. Learning to perform endoscopic resection of esophageal neoplasia is associated with significant complications even within a structured training program. Endoscopy. 2012 Jan;44(1):4-12.
• Pouw RE, van Vilsteren FG, Peters FP, Alvarez Herrero L, Ten Kate FJ, Visser M, Schenk BE, Schoon EJ, Peters FT, Houben M, Bisschops R, Weusten BL, Bergman JJ. Randomized trial on endoscopic resection-cap versus multiband mucosectomy for piecemeal endoscopic resection of early Barrett’s neoplasia. Gastrointest Endosc. 2011 Jul;74(1):35-43.
• Van Vilsteren FG, Alvarez Herrero L, Pouw RE, ten Kate FJ, Visser M, Seldenrijk CA, van Berge Henegouwen MI, Weusten BL, Bergman JJ. Radiofrequency ablation for the endoscopic eradication of esophageal squamous high grade intraepithelial neoplasia and mucosal squamous cell carcinoma. Endoscopy. 2011 Apr;43(4):282-90.
• Alvarez Herrero L, Pouw RE, van Vilsteren FG, ten Kate FJ, Visser M, Seldenrijk CA, van Berge Henegouwen MI, Weusten BL, Bergman JJ. Safety and efficacy of multiband mucosectomy in 1060 resections in Barrett’s esophagus. Endoscopy. 2011 Mar;43(3):177-83.
• Alvarez Herrero L, van Vilsteren FG, Pouw RE, ten Kate FJ, Visser M, Seldenrijk CA, van Berge Henegouwen MI, Fockens P, Weusten BL, Bergman JJ. Endoscopic radiofrequency ablation combined with endoscopic resection for early neoplasia in Barrett’s esophagus longer than 10 cm. Gastrointest Endosc. 2011 Apr;73(4):682-90.
• Pouw RE, Heldoorn N, Alvarez Herrero L, ten Kate FJ, Visser M, Busch OR, van Berge Henegouwen MI, Krishnadath KK, Weusten BL, Fockens P, Bergman JJ. Do we still need EUS in the workup of patients with early esophageal neoplasia? A retrospective analysis of 131 cases. Gastrointest Endosc. 2011 Apr;73(4):662-8.
• Van Vilsteren FG, Pouw RE, Seewald S, Alvarez Herrero L, Sondermeijer CM, Visser M, Ten Kate FJ, Yu Kim Teng KC, Soehendra N, Rösch T, Weusten BL, Bergman JJ. Stepwise radical endoscopic resection versus radiofrequency ablation for Barrett’s oesophagus with high-grade dysplasia or early cancer: a multicentre randomised trial. Gut. 2011 Jun;60(6):765-73.
• Curvers WL, van Vilsteren FG, Baak LC, Böhmer C, Mallant-Hent RC, Naber AH, van Oijen A, Ponsioen CY, Scholten P, Schenk E, Schoon E, Seldenrijk CA, Meijer GA, ten Kate FJ, Bergman JJ. Endoscopic trimodal imaging versus standard video endoscopy for detection of early Barrett’s neoplasia: a multicenter, randomized, crossover study in general practice. Gastrointest Endosc. 2011 Feb;73(2):195-203.
• Alvarez Herrero L, Pouw RE, van Vilsteren FG, ten Kate FJ, Visser M, van Berge Henegouwen MI, Weusten BL, Bergman JJ. Risk of lymph node metastasis associated with deeper invasion by early adenocarcinoma of the esophagus and cardia: study based on endoscopic resection specimens. Endoscopy. 2010 Dec;42(12):1030-6.
• Curvers WL, Alvarez Herrero L, Wallace MB, Wong Kee Song LM, Ragunath K, Wolfsen HC, Prasad GA, Wang KK, Subramanian V, Weusten BL, Ten Kate FJ, Bergman JJ. Endoscopic tri-modal imaging is more effective than standard endoscopy in identifying early-stage neoplasia in Barrett’s esophagus. Gastroenterology. 2010 Oct;139(4):1106-14.
• Pouw RE, Seewald S, Gondrie JJ, Deprez PH, Piessevaux H, Pohl H, Rösch T, Soehendra N, Bergman JJ. Stepwise radical endoscopic resection for eradication of Barrett’s oesophagus with early neoplasia in a cohort of 169 patients. Gut. 2010 Sep;59(9):1169-77.
• Curvers WL, ten Kate FJ, Krishnadath KK, Visser M, Elzer B, Baak LC, Bohmer C, Mallant-Hent RC, van Oijen A, Naber AH, Scholten P, Busch OR, Blaauwgeers HG, Meijer GA, Bergman JJ. Low-grade dysplasia in Barrett’s esophagus: overdiagnosed and underestimated. Am J Gastroenterol. 2010 Jul;105(7):1523-30.
• Pouw RE, Bergman JJ. Biased assessment of 3D optical coherence tomography in a single post-radiofrequency ablation patient without histological correlation. Endoscopy. 2010 Feb;42(2):179.
• Pouw RE, Wirths K, Eisendrath P, Sondermeijer CM, Ten Kate FJ, Fockens P, Devière J, Neuhaus H, Bergman JJ. Efficacy of radiofrequency ablation combined with endoscopic resection for barrett’s esophagus with early neoplasia. Clin Gastroenterol Hepatol. 2010 Jan;8(1):23-9.
• Pouw RE, Gondrie JJ, Rygiel AM, Sondermeijer CM, ten Kate FJ, Odze RD, Vieth M, Krishnadath KK, Bergman JJ. Properties of the neosquamous epithelium after radiofrequency ablation of Barrett’s esophagus containing neoplasia. Am J Gastroenterol. 2009 Jun;104(6):1366-73.
• Curvers WL, Singh R, Wallace MB, Song LM, Ragunath K, Wolfsen HC, ten Kate FJ, Fockens P, Bergman JJ. Identification of predictive factors for early neoplasia in Barrett’s esophagus after autofluorescence imaging: a stepwise multicenter structured assessment. Gastrointest Endosc. 2009 Jul;70(1):9-17.
• Alvarez Herrero L, Curvers WL, Bansal A, Wani S, Kara M, Schenk E, Schoon EJ, Lynch CR, Rastogi A, Pondugula K, Weusten B, Sharma P, Bergman JJ. Zooming in on Barrett oesophagus using narrow-band imaging: an international observer agreement study. Eur J Gastroenterol Hepatol. 2009 Sep;21(9):1068-75.
• Curvers WL, van den Broek FJ, Reitsma JB, Dekker E, Bergman JJ. Systematic review of narrow-band imaging for the detection and differentiation of abnormalities in the esophagus and stomach (with video). Gastrointest Endosc. 2009 Feb;69(2):307-17.
• Curvers WL, Bohmer CJ, Mallant-Hent RC, Naber AH, Ponsioen CI, Ragunath K, Singh R, Wallace MB, Wolfsen HC, Song LM, Lindeboom R, Fockens P, Bergman JJ. Mucosal morphology in Barrett’s esophagus: interobserver agreement and role of narrow band imaging. Endoscopy. 2008 Oct;40(10):799-805.
• Pouw RE, Gondrie JJ, Curvers WL, Sondermeijer CM, Ten Kate FJ, Bergman JJ. Successful balloon-based radiofrequency ablation of a widespread early squamous cell carcinoma and high-grade dysplasia of the esophagus: a case report. Gastrointest Endosc. 2008 Sep;68(3):537-41.
• Pouw RE, Gondrie JJ, Sondermeijer CM, ten Kate FJ, van Gulik TM, Krishnadath KK, Fockens P, Weusten BL, Bergman JJ. Eradication of Barrett esophagus with early neoplasia by radiofrequency ablation, with or without endoscopic resection. J Gastrointest Surg. 2008 Oct;12(10):1627-36; discussion 1636-7.
• Curvers WL, Peters FP, Elzer B, Schaap AJ, Baak LC, van Oijen A, Mallant-Hent RM, Ten Kate F, Krishnadath KK, Bergman JJ. Quality of Barrett’s surveillance in The Netherlands: a standardized review of endoscopy and pathology reports. Eur J Gastroenterol Hepatol. 2008 Jul;20(7):601-7.
• Gondrie JJ, Pouw RE, Sondermeijer CM, Peters FP, Curvers WL, Rosmolen WD, Ten Kate F, Fockens P, Bergman JJ. Effective treatment of early Barrett’s neoplasia with stepwise circumferential and focal ablation using the HALO system. Endoscopy. 2008 May;40(5):370-9.
• Gondrie JJ, Pouw RE, Sondermeijer CM, Peters FP, Curvers WL, Rosmolen WD, Krishnadath KK, Ten Kate F, Fockens P, Bergman JJ. Stepwise circumferential and focal ablation of Barrett’s esophagus with high-grade dysplasia: results of the first prospective series of 11 patients. Endoscopy. 2008 May;40(5):359-69.
• Peters FP, Curvers WL, Rosmolen WD, de Vries CE, Ten Kate FJ, Krishnadath KK, Fockens P, Bergman JJ. Surveillance history of endoscopically treated patients with early Barrett’s neoplasia: nonadherence to the Seattle biopsy protocol leads to sampling error. Dis Esophagus. 2008;21(6):475-9.
• Curvers W, Baak L, Kiesslich R, Van Oijen A, Rabenstein T, Ragunath K, Rey JF, Scholten P, Seitz U, Ten Kate F, Fockens P, Bergman J. Chromoendoscopy and narrow-band imaging compared with high-resolution magnification endoscopy in Barrett’s esophagus. Gastroenterology. 2008 Mar;134(3):670-9.
• Curvers WL, Singh R, Song LM, Wolfsen HC, Ragunath K, Wang K, Wallace MB, Fockens P, Bergman JJ. Endoscopic tri-modal imaging for detection of early neoplasia in Barrett’s oesophagus: a multi-centre feasibility study using high-resolution endoscopy, autofluorescence imaging and narrow band imaging incorporated in one endoscopy system. Gut. 2008 Feb;57(2):167-72.
• Peters FP, Brakenhoff KP, Curvers WL, Rosmolen WD, ten Kate FJ, Krishnadath KK, Fockens P, Bergman JJ. Endoscopic cap resection for treatment of early Barrett’s neoplasia is safe: a prospective analysis of acute and early complications in 216 procedures. Dis Esophagus. 2007;20(6):510-5.
• Peters FP, Kara MA, Curvers WL, Rosmolen WD, Fockens P, Krishnadath KK, Ten Kate FJ, Bergman JJ. Multiband mucosectomy for endoscopic resection of Barrett’s esophagus: feasibility study with matched historical controls. Eur J Gastroenterol Hepatol. 2007 Apr;19(4):311-5.
• Peters FP, Krishnadath KK, Rygiel AM, Curvers WL, Rosmolen WD, Fockens P, Ten Kate FJ, van Baal JW, Bergman JJ. Stepwise radical endoscopic resection of the complete Barrett’s esophagus with early neoplasia successfully eradicates pre-existing genetic abnormalities. Am J Gastroenterol. 2007 Sep;102(9):1853-61.
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